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Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

《医学前沿（英文）》 2021年 第15卷 第1期   页码 91-100 doi: 10.1007/s11684-020-0778-5

摘要： Congenital heart disease (CHD) is the most common birth defect worldwide. Long non-coding RNAs (lncRNAs) have been implicated in many diseases. However, their involvement in CHD is not well understood. This study aimed to investigate the role of dysregulated lncRNAs in CHD. We used Gene Expression Omnibus data mining, bioinformatics analysis, and analysis of clinical tissue samples and observed that the novel lncRNA SAP30-2:1 with unknown function was significantly downregulated in damaged cardiac tissues from patients with CHD. Knockdown of lncRNA SAP30-2:1 inhibited the proliferation of human embryonic kidney and AC16 cells and decreased the expression of heart and neural crest derivatives expressed 2 (HAND2). Moreover, lncRNA SAP30-2:1 was associated with HAND2 by RNA immunoprecipitation. Overall, these results suggest that lncRNA SAP30-2:1 may be involved in heart development through affecting cell proliferation via targeting HAND2 and may thus represent a novel therapeutic target for CHD.

关键词： congenital heart disease     Gene Expression Omnibus     lncRNA SAP30-2:1     cell proliferation     RNA immunoprecipitation     HAND2    

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Comparison of evapotranspiration and energy partitioning related to main biotic and abiotic controllers in vineyards using different irrigation methods

Lei GAO, Peng ZHAO, Shaozhong KANG, Sien LI, Ling TONG, Risheng DING, Hongna LU

《农业科学与工程前沿（英文）》 2020年 第7卷 第4期   页码 490-504 doi: 10.15302/J-FASE-2019310

摘要：

Knowledge of evapotranspiration (ET) and energy partitioning is useful for optimizing water management, especially in areas where water is scarce. A study was undertaken in a furrow-irrigated vineyard (2015) and a drip-irrigated vineyard (2017) in an arid region of north-west China to compare vineyard ET and energy partitioning and their responses to soil water content (SWC) and leaf area index (LAI). ET and soil evaporation (E) and transpiration (T) were determined using eddy covariance, microlysimeters, and sap flow. Seasonal average E/ET, T/ET, crop coefficient (Kc), evaporation coefficient (Ke), and basal crop coefficient (Kcb) were 0.50, 0.50, 0.67, 0.35, and 0.29, respectively, in the furrow-irrigated vineyard and 0.42, 0.58, 0.57, 0.29, and 0.43 in the drip-irrigated vineyard. The seasonal average partitioning of net radiation (Rn) into the latent heat flux (LE), sensible heat flux (H) and soil heat flux (G) (LE/Rn, H/Rn, and G/Rn), evaporative fraction (EF) and Bowen ratio (β) were 0.57, 0.26, 0.17, 0.69 and 0.63, respectively, in the furrow-irrigated vineyard and 0.46, 0.36, 0.17, 0.57 and 0.97 in the drip-irrigated vineyard. The LE/Rn, H/Rn, EF, and β were linearly correlated with LAI. The E, Kc, Ke, E/ET, LE/Rn, LEs/Rn (ratio of LE by soil E to Rn), H/Rn, EF and β were closely correlated with topsoil SWC (10 cm depth). Responses of ET and energy partitioning to the LAI and SWC differed under the two irrigation methods. Drip irrigation reduced seasonal average E/ET and increased average T/ET. From the perspective of energy partitioning, seasonal average H/Rn increased whereas LE/Rn, especially LEs/Rn, decreased. Compared with furrow irrigation, drip irrigation decreased the proportion of unproductive water consumption thereby contributing to enhanced water use efficiency and accumulation of dry matter.

关键词： crop coefficient     eddy covariance     microlysimeter     sap flow     soil evaporation     transpiration    

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Development of an integrated modeling system for improved multi-objective reservoir operation

Lei WANG, Cho Thanda NYUNT, Toshio KOIKE, Oliver SAAVEDRA, Lan Chau NGUYEN, Tran van SAP,

《结构与土木工程前沿（英文）》 2010年 第4卷 第1期   页码 47-55 doi: 10.1007/s11709-010-0001-x

摘要： Reservoir is an efficient way for flood control and improving all sectors related to water resources in the integrated water resources management. Moreover, multi-objective reservoir plays a significant role in the development of a country’s economy especially in developing countries. All multi-objective reservoirs have conflicts and disputes in flood control and water use, which makes the operator a great challenge in the decision of reservoir operation. For improved multi-objective reservoir operation, an integrated modeling system has been developed by incorporating a global optimization system (SCE-UA) into a distributed biosphere hydrological model (WEB-DHM) coupled with the reservoir routing module. The new integrated modeling system has been tested in the Da River subbasin of the Red River and showed the capability of reproducing observed reservoir inflows and optimizing the multi-objective reservoir operation. First, the WEB-DHM was calibrated for the inflows to the Hoa Binh Reservoir in the Da River. Second, the WEB-DHM coupled with the reservoir routing module was tested by simulating the reservoir water level, when using the observed dam outflows as the reservoir release. Third, the new integrated modeling system was evaluated by optimizing the operation rule of the Hoa Binh Reservoir from 1 June to 28 July 2006, which covered the annual largest flood peak. By using the optimal rule for the reservoir operation, the annual largest flood peak at downstream control point (Ben Ngoc station) was successfully reduced (by about 2.4m for water level and 2500m·s for discharge); while after the simulation periods, the reservoir water level was increased by about 20m that could supply future water use.

关键词： distributed biosphere hydrological model (WEB-DHM)     optimization     multi-objective reservoir     the Red River basin    

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Treatment of severe acute pancreatitis through retroperitoneal laparoscopic drainage

Chun Tang, Baolin Wang, Bing Xie, Hongming Liu, Ping Chen

《医学前沿（英文）》 2011年 第5卷 第3期   页码 302-305 doi: 10.1007/s11684-011-0145-7

摘要： A treatment method based on drainage via retroperitoneal laparoscopy was adopted for 15 severe acute pancreatitis (SAP) patients to investigate the feasibility of the method. Ten patients received only drainage via retroperitoneal laparoscopy, four patients received drainage via both retroperitoneal and preperitoneal laparoscopy, and one patient received drainage via conversion to laparotomy. Thirteen patients exhibited a good drainage effect and were successfully cured without any other surgical treatment. Two patients had encapsulated effusions or pancreatic pseudocysts after surgery, but were successfully cured after lavage and B ultrasound-guided percutaneous catheter drainage. SAP treatment via retroperitoneal laparoscopic drainage is an effective surgical method, resulting in minor injury.

关键词： severe acute pancreatitis (SAP)     laparoscope     retroperitoneal drainage     treatment    

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Numerical study of internal flow field and flow passage improvement of an inlet particle separator

Florian PAOLI, Tong WANG

《能源前沿（英文）》 2011年 第5卷 第4期   页码 386-397 doi: 10.1007/s11708-011-0156-8

摘要： By performing gas flow field numerical simulations for several inlet Reynolds numbers (from 2 × 10 to 9 × 10 ) and byflow ratios (from 10% to 20%), the present study has proposed to improve the flow passage of an inlet particle separator. An adjacent objective of the study is to lower pressure losses of the inlet particle separator (IPS). No particle has been included in the gas flow for a -epsilon turbulence model. The velocity distribution in different sections and the pressure coefficient along the duct have been analyzed, which indicates that there exist important low-velocity regions and vortices in the separation area. Therefore, the profile of streamlines along the original passage has been considered. This profile illustrated a vacuum region in the same area. All investigations suggest that the separation area is the most critical one for fulfilling the objective on pressure losses limitation. Then the flow passage improvement method has focused on the separation area. An improved shape has been designed in order to suit smoothly to the streamlines in this region. Similar numerical studies as those for the original shape have been conducted on this improved shape, confirming some considerable enhancements compared with the original shape. The significant vortices which appear in the original shape reduce in amount and size. Besides, pressure losses are greatly decreased in both outlets (up to 30% for high Reynolds number) and the flow is uniform at the main outlet. Subsequent engineering surveys could rely on expressions obtained for in both outlets which extend the pressure losses for a wide range of inlet Reynolds numbers. As a result, the numerical calculations demonstrate that the flow passage improvement method applied in this study has succeeded in designing a shape which enhances the flow behavior.

关键词： streamlines     pressure losses     flow passage improvement     inlet particle separator (IPS)    

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Optimal design of double-layer barrel vaults using genetic and pattern search algorithms and optimized neural network as surrogate model

《结构与土木工程前沿（英文）》 2023年 第17卷 第3期   页码 378-395 doi: 10.1007/s11709-022-0899-9

摘要： This paper presents a combined method based on optimized neural networks and optimization algorithms to solve structural optimization problems. The main idea is to utilize an optimized artificial neural network (OANN) as a surrogate model to reduce the number of computations for structural analysis. First, the OANN is trained appropriately. Subsequently, the main optimization problem is solved using the OANN and a population-based algorithm. The algorithms considered in this step are the arithmetic optimization algorithm (AOA) and genetic algorithm (GA). Finally, the abovementioned problem is solved using the optimal point obtained from the previous step and the pattern search (PS) algorithm. To evaluate the performance of the proposed method, two numerical examples are considered. In the first example, the performance of two algorithms, OANN + AOA + PS and OANN + GA + PS, is investigated. Using the GA reduces the elapsed time by approximately 50% compared with using the AOA. Results show that both the OANN + GA + PS and OANN + AOA + PS algorithms perform well in solving structural optimization problems and achieve the same optimal design. However, the OANN + GA + PS algorithm requires significantly fewer function evaluations to achieve the same accuracy as the OANN + AOA + PS algorithm.

关键词： optimization     surrogate models     artificial neural network     SAP2000     genetic algorithm    

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物质流分析的跟踪观察法

陆钟武

《中国工程科学》 2006年 第8卷 第1期   页码 18-25

摘要：

流动，是物质（如铜、铝等）流动和流体流动二者所具有的基本特征，基于这个论点，简要地回顾了流体力学中研究流体流动的两种方法，即拉格朗日法和欧拉法；相应地提出了物质流分析的两种方法，即跟踪观察法和定点观察法。由于前者在文献中未见报道，因此对它进行了重点说明。强调了物质流的跟踪观察法既适用于稳态物质流（产品产量不变），也适用于非稳态物质流（产品产量增长或下降）。以钢铁产品生命周期的铁流图为例，说明了物质流的跟踪模型。在引入了物质流的非稳度后，提出了物质流各项指标的计算式，以及它们之间的相互关系。以瑞典铅酸电池系统为对象，计算了其中铅流的各项指标，并进行了必要的分析。

关键词： 物质流的研究方法     物质流的跟踪观察法     物质流的基本公式     物质流的非稳度    

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UPFC setting to avoid active power flow loop considering wind power uncertainty

Shenghu LI, Ting WANG

《能源前沿（英文）》 2023年 第17卷 第1期   页码 165-175 doi: 10.1007/s11708-020-0686-z

摘要： The active power loop flow (APLF) may be caused by impropriate network configuration, impropriate parameter settings, and/or stochastic bus powers. The power flow controllers, e.g., the unified power flow controller (UPFC), may be the reason and the solution to the loop flows. In this paper, the critical existence condition of the APLF is newly integrated into the simultaneous power flow model for the system and UPFC. Compared with the existing method of alternatively solving the simultaneous power flow and sensitivity-based approaching to the critical existing condition, the integrated power flow needs less iterations and calculation time. Besides, with wind power fluctuation, the interval power flow (IPF) is introduced into the integrated power flow, and solved with the affine Krawcyzk iteration to make sure that the range of active power setting of the UPFC not yielding the APLF. Compared with Monte Carlo simulation, the IPF has the similar accuracy but less time.

关键词： active power loop flow (APLF)     unified power flow controller (UPFC)     wind power uncertainty     interval power flow (IPF)    

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A novel flow electrode capacitive deionization device with spindle-shaped desalting chamber

《环境科学与工程前沿（英文）》 2023年 第18卷 第4期 doi: 10.1007/s11783-024-1800-y

摘要：

● A spindle-shaped influent chamber was designed and equipped in FCDI system.

关键词： Spindle-shaped chamber     Desalination performance     Flow electrode capacitive deionization    

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Simulation of horizontal slug-flow pneumatic conveying with kinetic theory

GU Zhengmeng, GUO Liejin

《能源前沿（英文）》 2007年 第1卷 第3期   页码 336-340 doi: 10.1007/s11708-007-0050-6

摘要： Wavelike slug-flow is a representative flow type in horizontal pneumatic conveying. Kinetic theory was introduced to establish a 3D kinetic numerical model for wavelike slug gas-solid flow in this paper. Wavelike motion of particulate slugs in horizontal pipes was numerically investigated. The formation and motion process of slugs and settled layer were simulated. The characteristics of the flow, such as pressure drop, air velocity distribution, slug length and settled layer thickness, and the detailed changing characteristics of slug length and settled layer thickness with air velocity were obtained. The results indicate that kinetic theory can represent the physical characteristics of the non-suspension dense phase flow of wavelike slug pneumatic conveying. The experiment in this paper introduced a new idea for the numerical calculation of slug-flow pneumatic conveying.

关键词： velocity distribution     detailed     slug-flow     gas-solid     theory    

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Characterization and comparison of organic functional groups effects on electrolyte performance for vanadium redox flow

《化学科学与工程前沿（英文）》 2023年 第17卷 第9期   页码 1221-1230 doi: 10.1007/s11705-023-2298-8

摘要： The vanadium redox flow battery with a safe and capacity-controllable large-scale energy storage system offers a new method for the sustainability. In this case, acetic acid, methane sulfonic acid, sulfonic acid, amino methane sulfonic acid, and taurine are used to overcome the low electrolyte energy density and stability limitations, as well as to investigate the effects of various organic functional groups on the vanadium redox flow battery. When compared to the pristine electrolyte (0.22 Ah, 5.0 Wh·L–1, 85.0%), the results show that taurine has the advantage of maintaining vanadium ion concentrations, discharge capacity (1.43 Ah), energy density (33.9 Wh·L–1), and energy efficiency (90.5%) even after several cycles. The acetic acid electrolyte is more conducive to the low-temperature stability of the V(II) electrolyte (177 h at −25 °C) than pristine (82 h at −2 °C). The –SO3H group, specifically the coaction of the –NH2 and –SO3H groups, improves electrolyte stability. The –NH2 and –COOH additive groups improved conductivity and electrochemical activity.

关键词： vanadium redox flow battery     functional groups     organic additives     energy density     stability    

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Experimental study on combined buoyant-thermocapillary flow along with rising liquid film on the surface

Manuel J. GOMES, Ning MEI

《能源前沿（英文）》 2020年 第14卷 第1期   页码 114-126 doi: 10.1007/s11708-017-0483-5

摘要： Temperature distribution and variation with time has been considered in the analysis of the influences of the initial level of immersion of a horizontal metallic mesh tube in the liquid on combined buoyant and thermo-capillary flow. The combined flow occurs along with the rising liquid film flow on the surface of a horizontal metallic mesh tube. Three different levels of immersion of the metallic mesh tube in the liquid have been tested. Experiments of 60 min in duration have been performed using a heating metallic tube with a diameter of 25 mm and a length of 110 mm, sealed outside with a metallic mesh of 178 mm by 178 mm, and distilled water. These reveal two distinct flow patterns. Thermocouples and infrared thermal imager are utilized to measure the temperature. The level of the liquid free surface relative to the lower edge of the tube is measured as angle . The results show that for a smaller angle, or a low level of immersion, with a relatively low heating power, it is possible to near fully combine the upwards buoyant flow with the rising liquid film flow. In this case, the liquid is heated only in the vicinity of the tube, while the liquid away from the flow region experiences small changes in temperature and the system approaches steady conditions. For larger angles, or higher levels of immersion, a different flow pattern is noticed on the liquid free surface and identified as the thermo-capillary (Marangoni) flow. The rising liquid film is also present. The higher levels of immersion cause a high temperature gradient in the liquid free surface region and promote thermal stratification; therefore the system could not approach steady conditions.

关键词： rising liquid film     combined flow     thermo-capillary flow     buoyant flow     metallic mesh tube     horizontal tube    

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Comparison of membrane fouling in ultrafiltration of down-flow and up-flow biological activated carbon

Lu Ao, Wenjun Liu, Yang Qiao, Cuiping Li, Xiaomao Wang

《环境科学与工程前沿（英文）》 2018年 第12卷 第6期 doi: 10.1007/s11783-018-1046-7

摘要：

The UF membrane fouling by down- and up-flow BAC effluents were compared.

Up-flow BAC effluent fouled the membrane faster than down-flow BAC effluent.

The combined effects dominated irreversible fouling.

The extent of fouling exacerbated by inorganic particles was higher.

关键词： Ultrafiltration     Membrane fouling     Down-flow biological activated carbon     Up-flow biological activated carbon     Particles     Polysaccharide    

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GIS-based numerical simulation of Amamioshima debris flow in Japan

Jian WU, Guangqi CHEN, Lu ZHENG, Yingbin ZHANG

《结构与土木工程前沿（英文）》 2013年 第7卷 第2期   页码 206-214 doi: 10.1007/s11709-013-0198-6

摘要： Debris flow is a rapid flow which could lead to severe flooding with catastrophic consequences such as damage to properties and loss of human lives. It is important to study the movement of debris flow. Since during a debris flow process, the erosion and deposition processes are important, the no entrainment assumption is not acceptable. In this study, first we considered the debris flow as equivalent fluid and adopted the depth-averaged govern equations to simulate the movements and evolution of river bed. Secondly, the set of partial differential equations was solved numerically by means of explicit staggered leap-frog scheme that is accurate in space and time. The grid of difference scheme was derived from GIS raster data. Then the simulation results can be displayed by GIS and easily used to form the hazard maps. Finally, the numerical model coupled with GIS is applied to simulate the debris flow occurred on Oct. 20th, 2010, in Amamioshima City, Japan. The simulation reproduces the movement, erosion and deposition. The results are shown to be consistent with the field investigation.

关键词： debris flow     numerical simulation     GIS     movement     erosion     deposition    

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Burnett simulations of gas flow and heat transfer in microchannels

Fubing BAO, Jianzhong LIN

《机械工程前沿（英文）》 2009年 第4卷 第3期   页码 252-263 doi: 10.1007/s11465-009-0037-6

摘要： In micro- and nanoscale gas flows, the flow falls into the transition flow regime. There are not enough molecule collisions and the gas deviates from the equilibrium. The Navier-Stokes equations fail to describe the gas flow in this regime. The direct simulation Monte Carlo method converges slowly and requires lots of computational time. As a result, the high-order Burnett equations are used to study the gas flow and heat transfer characteristics in micro- and nanoscale gas flows in this paper. The Burnett equations are first reviewed, and the augmented Burnett equations with high-order slip boundary conditions are then used to model the gas flow and heat transfer in Couette and Poiseuille flows in the transition regime.

关键词： micro- and nanoscale gas flow     slip-transition flow regime     Burnett equations     numerical simulation    

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标题 作者 时间 类型 操作

Long non-coding RNA SAP30-2:1 is downregulated in congenital heart disease and regulates cell proliferation

Jing Ma, Shiyu Chen, Lili Hao, Wei Sheng, Weicheng Chen, Xiaojing Ma, Bowen Zhang, Duan Ma, Guoying Huang

期刊论文

Comparison of evapotranspiration and energy partitioning related to main biotic and abiotic controllers in vineyards using different irrigation methods

Lei GAO, Peng ZHAO, Shaozhong KANG, Sien LI, Ling TONG, Risheng DING, Hongna LU

期刊论文

Development of an integrated modeling system for improved multi-objective reservoir operation

Lei WANG, Cho Thanda NYUNT, Toshio KOIKE, Oliver SAAVEDRA, Lan Chau NGUYEN, Tran van SAP,

期刊论文

Treatment of severe acute pancreatitis through retroperitoneal laparoscopic drainage

Chun Tang, Baolin Wang, Bing Xie, Hongming Liu, Ping Chen

期刊论文

Numerical study of internal flow field and flow passage improvement of an inlet particle separator

Florian PAOLI, Tong WANG

期刊论文

Optimal design of double-layer barrel vaults using genetic and pattern search algorithms and optimized neural network as surrogate model

期刊论文

物质流分析的跟踪观察法

陆钟武

期刊论文

UPFC setting to avoid active power flow loop considering wind power uncertainty

Shenghu LI, Ting WANG

期刊论文

A novel flow electrode capacitive deionization device with spindle-shaped desalting chamber

期刊论文

Simulation of horizontal slug-flow pneumatic conveying with kinetic theory

GU Zhengmeng, GUO Liejin

期刊论文

Characterization and comparison of organic functional groups effects on electrolyte performance for vanadium redox flow

期刊论文

Experimental study on combined buoyant-thermocapillary flow along with rising liquid film on the surface

Manuel J. GOMES, Ning MEI

期刊论文

Comparison of membrane fouling in ultrafiltration of down-flow and up-flow biological activated carbon

Lu Ao, Wenjun Liu, Yang Qiao, Cuiping Li, Xiaomao Wang

期刊论文

GIS-based numerical simulation of Amamioshima debris flow in Japan

Jian WU, Guangqi CHEN, Lu ZHENG, Yingbin ZHANG

期刊论文

Burnett simulations of gas flow and heat transfer in microchannels

Fubing BAO, Jianzhong LIN

期刊论文